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cell lines vcap atcc cat  (ATCC)
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ATCC cell lines vcap atcc cat
Cell Lines Vcap Atcc Cat, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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vcap cells  (ATCC)
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ATCC vcap cells
Vectra and IMC analysis reveals castration-induced dynamic changes in AR +/- BCL-2 +/- cell types in 4 xenograft CRPC models. a – d tSNE plots of IMC-derived single-cell imaging data. Shown are the individual and merged tSNE plots <t>from</t> <t>LNCaP-AD/AI</t> ( a ), LAPC9-AD/AI ( b ), LAPC4-AD/AI ( c ), and <t>VCaP-AD/AI</t> ( d ) xenografts. Columns represent merged AD and AI cell clusters (first column), individual AD and AI cell populations and contours (second and third columns), and AR and BCL-2 expression overlaid on tSNE maps (fourth and fifth columns). Blue and red contours indicate AD and AI cell subpopulations, respectively. e LAPC4-AD tumors are populated mostly by AR + BCL-2 - PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images (scale bar, 80 μm for all panels). f LAPC4-AI (1° CRPC) tumors are populated by AR cyto BCL-2 + PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images illustrating cytoplasmic AR + LAPC4-AI cells with upregulated BCL-2 (scale bar, 80 μm for all panels). g IMC images of AR and BCL-2 in LAPC4-AD and LAPC4-AI tumors (scale bar, 200 μm) with representative zoom-in images of AR and BCL-2 shown below (scale bar, 100 μm for all panels)
Vcap Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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vcap cells - by Bioz Stars, 2026-05
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vcap cell lines  (ATCC)
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ATCC vcap cell lines
Vectra and IMC analysis reveals castration-induced dynamic changes in AR +/- BCL-2 +/- cell types in 4 xenograft CRPC models. a – d tSNE plots of IMC-derived single-cell imaging data. Shown are the individual and merged tSNE plots <t>from</t> <t>LNCaP-AD/AI</t> ( a ), LAPC9-AD/AI ( b ), LAPC4-AD/AI ( c ), and <t>VCaP-AD/AI</t> ( d ) xenografts. Columns represent merged AD and AI cell clusters (first column), individual AD and AI cell populations and contours (second and third columns), and AR and BCL-2 expression overlaid on tSNE maps (fourth and fifth columns). Blue and red contours indicate AD and AI cell subpopulations, respectively. e LAPC4-AD tumors are populated mostly by AR + BCL-2 - PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images (scale bar, 80 μm for all panels). f LAPC4-AI (1° CRPC) tumors are populated by AR cyto BCL-2 + PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images illustrating cytoplasmic AR + LAPC4-AI cells with upregulated BCL-2 (scale bar, 80 μm for all panels). g IMC images of AR and BCL-2 in LAPC4-AD and LAPC4-AI tumors (scale bar, 200 μm) with representative zoom-in images of AR and BCL-2 shown below (scale bar, 100 μm for all panels)
Vcap Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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vcap cell lines - by Bioz Stars, 2026-05
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brd4 western blot vcap cells  (ATCC)
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ATCC brd4 western blot vcap cells
Vectra and IMC analysis reveals castration-induced dynamic changes in AR +/- BCL-2 +/- cell types in 4 xenograft CRPC models. a – d tSNE plots of IMC-derived single-cell imaging data. Shown are the individual and merged tSNE plots <t>from</t> <t>LNCaP-AD/AI</t> ( a ), LAPC9-AD/AI ( b ), LAPC4-AD/AI ( c ), and <t>VCaP-AD/AI</t> ( d ) xenografts. Columns represent merged AD and AI cell clusters (first column), individual AD and AI cell populations and contours (second and third columns), and AR and BCL-2 expression overlaid on tSNE maps (fourth and fifth columns). Blue and red contours indicate AD and AI cell subpopulations, respectively. e LAPC4-AD tumors are populated mostly by AR + BCL-2 - PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images (scale bar, 80 μm for all panels). f LAPC4-AI (1° CRPC) tumors are populated by AR cyto BCL-2 + PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images illustrating cytoplasmic AR + LAPC4-AI cells with upregulated BCL-2 (scale bar, 80 μm for all panels). g IMC images of AR and BCL-2 in LAPC4-AD and LAPC4-AI tumors (scale bar, 200 μm) with representative zoom-in images of AR and BCL-2 shown below (scale bar, 100 μm for all panels)
Brd4 Western Blot Vcap Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ar elisa assay vcap cells  (ATCC)
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ATCC ar elisa assay vcap cells
Vectra and IMC analysis reveals castration-induced dynamic changes in AR +/- BCL-2 +/- cell types in 4 xenograft CRPC models. a – d tSNE plots of IMC-derived single-cell imaging data. Shown are the individual and merged tSNE plots <t>from</t> <t>LNCaP-AD/AI</t> ( a ), LAPC9-AD/AI ( b ), LAPC4-AD/AI ( c ), and <t>VCaP-AD/AI</t> ( d ) xenografts. Columns represent merged AD and AI cell clusters (first column), individual AD and AI cell populations and contours (second and third columns), and AR and BCL-2 expression overlaid on tSNE maps (fourth and fifth columns). Blue and red contours indicate AD and AI cell subpopulations, respectively. e LAPC4-AD tumors are populated mostly by AR + BCL-2 - PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images (scale bar, 80 μm for all panels). f LAPC4-AI (1° CRPC) tumors are populated by AR cyto BCL-2 + PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images illustrating cytoplasmic AR + LAPC4-AI cells with upregulated BCL-2 (scale bar, 80 μm for all panels). g IMC images of AR and BCL-2 in LAPC4-AD and LAPC4-AI tumors (scale bar, 200 μm) with representative zoom-in images of AR and BCL-2 shown below (scale bar, 100 μm for all panels)
Ar Elisa Assay Vcap Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human prostate cancer cell lines vcap  (ATCC)
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ATCC human prostate cancer cell lines vcap
Vectra and IMC analysis reveals castration-induced dynamic changes in AR +/- BCL-2 +/- cell types in 4 xenograft CRPC models. a – d tSNE plots of IMC-derived single-cell imaging data. Shown are the individual and merged tSNE plots <t>from</t> <t>LNCaP-AD/AI</t> ( a ), LAPC9-AD/AI ( b ), LAPC4-AD/AI ( c ), and <t>VCaP-AD/AI</t> ( d ) xenografts. Columns represent merged AD and AI cell clusters (first column), individual AD and AI cell populations and contours (second and third columns), and AR and BCL-2 expression overlaid on tSNE maps (fourth and fifth columns). Blue and red contours indicate AD and AI cell subpopulations, respectively. e LAPC4-AD tumors are populated mostly by AR + BCL-2 - PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images (scale bar, 80 μm for all panels). f LAPC4-AI (1° CRPC) tumors are populated by AR cyto BCL-2 + PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images illustrating cytoplasmic AR + LAPC4-AI cells with upregulated BCL-2 (scale bar, 80 μm for all panels). g IMC images of AR and BCL-2 in LAPC4-AD and LAPC4-AI tumors (scale bar, 200 μm) with representative zoom-in images of AR and BCL-2 shown below (scale bar, 100 μm for all panels)
Human Prostate Cancer Cell Lines Vcap, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human prostate cancer cell lines vcap - by Bioz Stars, 2026-05
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vcap human prostate cancer cell line  (ATCC)
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ATCC vcap human prostate cancer cell line
Vectra and IMC analysis reveals castration-induced dynamic changes in AR +/- BCL-2 +/- cell types in 4 xenograft CRPC models. a – d tSNE plots of IMC-derived single-cell imaging data. Shown are the individual and merged tSNE plots <t>from</t> <t>LNCaP-AD/AI</t> ( a ), LAPC9-AD/AI ( b ), LAPC4-AD/AI ( c ), and <t>VCaP-AD/AI</t> ( d ) xenografts. Columns represent merged AD and AI cell clusters (first column), individual AD and AI cell populations and contours (second and third columns), and AR and BCL-2 expression overlaid on tSNE maps (fourth and fifth columns). Blue and red contours indicate AD and AI cell subpopulations, respectively. e LAPC4-AD tumors are populated mostly by AR + BCL-2 - PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images (scale bar, 80 μm for all panels). f LAPC4-AI (1° CRPC) tumors are populated by AR cyto BCL-2 + PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images illustrating cytoplasmic AR + LAPC4-AI cells with upregulated BCL-2 (scale bar, 80 μm for all panels). g IMC images of AR and BCL-2 in LAPC4-AD and LAPC4-AI tumors (scale bar, 200 μm) with representative zoom-in images of AR and BCL-2 shown below (scale bar, 100 μm for all panels)
Vcap Human Prostate Cancer Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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vcap human prostate cancer cell line - by Bioz Stars, 2026-05
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Vectra and IMC analysis reveals castration-induced dynamic changes in AR +/- BCL-2 +/- cell types in 4 xenograft CRPC models. a – d tSNE plots of IMC-derived single-cell imaging data. Shown are the individual and merged tSNE plots from LNCaP-AD/AI ( a ), LAPC9-AD/AI ( b ), LAPC4-AD/AI ( c ), and VCaP-AD/AI ( d ) xenografts. Columns represent merged AD and AI cell clusters (first column), individual AD and AI cell populations and contours (second and third columns), and AR and BCL-2 expression overlaid on tSNE maps (fourth and fifth columns). Blue and red contours indicate AD and AI cell subpopulations, respectively. e LAPC4-AD tumors are populated mostly by AR + BCL-2 - PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images (scale bar, 80 μm for all panels). f LAPC4-AI (1° CRPC) tumors are populated by AR cyto BCL-2 + PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images illustrating cytoplasmic AR + LAPC4-AI cells with upregulated BCL-2 (scale bar, 80 μm for all panels). g IMC images of AR and BCL-2 in LAPC4-AD and LAPC4-AI tumors (scale bar, 200 μm) with representative zoom-in images of AR and BCL-2 shown below (scale bar, 100 μm for all panels)

Journal: Signal Transduction and Targeted Therapy

Article Title: Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer

doi: 10.1038/s41392-026-02700-w

Figure Lengend Snippet: Vectra and IMC analysis reveals castration-induced dynamic changes in AR +/- BCL-2 +/- cell types in 4 xenograft CRPC models. a – d tSNE plots of IMC-derived single-cell imaging data. Shown are the individual and merged tSNE plots from LNCaP-AD/AI ( a ), LAPC9-AD/AI ( b ), LAPC4-AD/AI ( c ), and VCaP-AD/AI ( d ) xenografts. Columns represent merged AD and AI cell clusters (first column), individual AD and AI cell populations and contours (second and third columns), and AR and BCL-2 expression overlaid on tSNE maps (fourth and fifth columns). Blue and red contours indicate AD and AI cell subpopulations, respectively. e LAPC4-AD tumors are populated mostly by AR + BCL-2 - PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images (scale bar, 80 μm for all panels). f LAPC4-AI (1° CRPC) tumors are populated by AR cyto BCL-2 + PCa cells. Shown on top are qmIF WM images (scale bar, 800 μm) and at the bottom zoom-in images illustrating cytoplasmic AR + LAPC4-AI cells with upregulated BCL-2 (scale bar, 80 μm for all panels). g IMC images of AR and BCL-2 in LAPC4-AD and LAPC4-AI tumors (scale bar, 200 μm) with representative zoom-in images of AR and BCL-2 shown below (scale bar, 100 μm for all panels)

Article Snippet: LNCaP, LAPC4 and VCaP cells were purchased from the American Type Culture Collection (ATCC) and cultured in RPMI-1640 medium (for LNCaP) or DMEM (for LAPC4 and VCaP) plus 10% heat-inactivated fetal bovine serum (FBS) and antibiotics.

Techniques: Derivative Assay, Single Cell, Imaging, Expressing